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| DNA copy number losses in human neoplasms |
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| Author(s): Knuutila S, Aalto Y, Autio K, Bjorkqvist AM, El-Rifai W, Hemmer S, Huhta T, Kettunen E, Kiuru-Kuhlefelt S, Larramendy ML, Lushnikova T, Monni O, Pere H, Tapper J, Tarkkanen M, Varis A, Wasenius VM, Wolf M, Zhu Y |
| Source: AMERICAN JOURNAL OF PATHOLOGY Volume: 155 Issue: 3 Pages: 683-694 Published: SEP 1999 |
| Times Cited: 250 References: 197 |
| Abstract: This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/similar to IgI_www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22-q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22-q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types. |
| Document Type: Review |
| Language: English |
| Reprint Address: Knuutila, S (reprint author), Univ Helsinki, Cent Hosp, Dept Med Genet, POB 404,Haartmaninkatu 3,4th Floor, FIN-00029 Helsinki, Finland |
Addresses:
1. Univ Helsinki, Cent Hosp, Dept Med Genet, FIN-00029 Helsinki, Finland
2. Haartman Inst, Dept Med Genet, Helsinki, Finland
3. Univ Helsinki, Cent Hosp, Dept Oncol, Helsinki, Finland
4. Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, Helsinki, Finland |
| Publisher: AMER SOC INVESTIGATIVE PATHOLOGY, INC, 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 USA |
| Subject Category: Pathology |
| IDS Number: 235JD |
| ISSN: 0002-9440 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |