| | |  | | | | Record from Web of Science® | | | | | | |
| The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis |
|
|
| Author(s): Battista S, Fidanza V, Fedele M, Klein-Szanto AJP, Outwater E, Brunner H, Santoro M, Croce CM, Fusco A |
| Source: CANCER RESEARCH Volume: 59 Issue: 19 Pages: 4793-4797 Published: OCT 1 1999 |
| Times Cited: 104 References: 19 |
| Abstract: Rearrangements of the HMGI-C gene have frequently been detected in human benign tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook domains and an acidic COOH-terminal tail, The HMGI-C modifications consist in the loss of the C-tail and the fusion with ectopic sequences, Recent results show that the loss of the COOH-terminal region, rather than the acquisition of new sequences, is sufficient to confer to HMGI-C the ability to transform NIH3T3 cells. Therefore, transgenic mice carrying a HMGI-C construct (HMGI-C/T), containing only the three AT-hook domains, were generated. The HIMGI-C/T mice showed a giant phenotype, together,vith a predominantly abdominal/pelvic lipomatosis, suggesting a pivotal role of the HMGI-C truncation in the generation of human lipomas. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fusco, A (reprint author), Univ Naples Federico II, Fac Med & Chirurg, CNR, Ctr Endocrinol & Oncol Sperimentale,Dipartimento, Via Pansini 5, I-80131 Naples, Italy |
Addresses:
1. Univ Naples Federico II, Fac Med & Chirurg, CNR, Ctr Endocrinol & Oncol Sperimentale,Dipartimento, I-80131 Naples, Italy
2. Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
3. Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
4. Thomas Jefferson Univ, Jefferson Med Coll, Image Ctr, Philadelphia, PA 19107 USA
5. Univ Nijmegen Hosp, Dept Clin Genet, NL-417 Nijmegen, Netherlands
6. Univ Catanzaro, Fac Med & Chirurg, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 244AC |
| ISSN: 0008-5472 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |