| | |  | | | | Record from Web of Science® | | | | | | |
| Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+ |
|
|
| Author(s): Adkins CE, Taylor CW |
| Source: CURRENT BIOLOGY Volume: 9 Issue: 19 Pages: 1115-1118 Published: OCT 7 1999 |
| Times Cited: 72 References: 22 |
| Abstract: Ryanodine and inositol 1,4,5-trisphosphate (IP3) receptors - two related families of Ca2+ channels responsible for release of Ca2+ from intracellular stores [1] - are biphasically regulated by cytosolic Ca2+ [2-4], it is thought that the resulting positive feedback allows localised Ca2+ release events to propagate regeneratively, and that the negative feedback limits the amplitude of individual events [5,6]. Stimulation of IP3 receptors by Ca2+ occurs through a Ca2+ binding site that becomes exposed only after in, has bound to its receptor [7,8]. Here, we report that rapid inhibition of IP3 receptors by Ca2+ occurs only if the receptor has not bound IP3. The IP3, therefore switches its receptor from a state in which only an inhibitory Ca2+-binding site is accessible to one in which only a stimulatory site is available. This regulation ensures that Ca2+ released by an active IP3 receptor may rapidly inhibit its unliganded neighbours, but it cannot terminate the activity of a receptor with IP3 bound. Such lateral inhibition, which is a universal feature of sensory systems where it improves contrast and dynamic range, may fulfil similar roles in intracellular Ca2+ signalling by providing increased sensitivity to in, and allowing rapid graded recruitment of IP3 receptors. |
| Document Type: Article |
| Language: English |
| Reprint Address: Taylor, CW (reprint author), Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1QJ, England |
Addresses:
1. Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 244VQ |
| ISSN: 0960-9822 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |