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| Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair |
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| Author(s): Munz B, Smola H, Engelhardt F, Bleuel K, Brauchle M, Lein I, Evans LW, Huylebroeck D, Balling R, Werner S |
| Source: EMBO JOURNAL Volume: 18 Issue: 19 Pages: 5205-5215 Published: OCT 1 1999 |
| Times Cited: 107 References: 46 |
| Abstract: Recently we demonstrated a strong induction of activin expression after skin injury, suggesting a function of this transforming growth factor-beta family member in wound repair. To test this possibility, we generated transgenic mice that overexpress the activin beta A chain in the epidermis under the control of a keratin 14 promoter. The transgenic mice were significantly smaller than control littermates, and they had smaller ears and shorter tails. In their skin, the fatty tissue was replaced by connective tissue and a severe thickening of the epidermis was found. The spinous cell layer was significantly increased, and the epidermal architecture was highly disorganized. These histological abnormalities seem to result from increased proliferation of the basal keratinocytes and abnormalities in the program of keratinocyte differentiation. After skin injury, a significant enhancement of granulation tissue formation was detected in the activin-overexpressing mice, possibly as a result of premature induction of fibronectin and tenascin-C expression. These data reveal novel activities of activin in the regulation of keratinocyte proliferation and differentiation as well as in dermal fibrosis and cutaneous wound repair. |
| Document Type: Article |
| Language: English |
| Reprint Address: Werner, S (reprint author), ETH Honggerberg, Inst Cell Biol, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland |
Addresses:
1. ETH Honggerberg, Inst Cell Biol, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland
2. Max Planck Inst Biochem, D-82152 Martinsried, Germany
3. Univ Cologne, Klin Dermatol & Venerol, D-50924 Cologne, Germany
4. Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England
5. Katholieke Univ Leuven VIB, Dept Cell Growth Differentiat & Dev VIB07, B-3000 Leuven, Belgium
6. Katholieke Univ Leuven, Lab Mol Biol CELGEN, B-3000 Leuven, Belgium
7. GSF Forschungszentrum Umwelt & Gesundheit, Inst Saugetiergenet, D-85764 Neuherberg, Germany |
| Publisher: OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 246AK |
| ISSN: 0261-4189 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |