| | |  | | | | Record from Web of Science® | | | | | | |
| A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice |
|
|
| Author(s): Chen JF, Huang ZH, Ma JY, Zhu JM, Moratalla R, Standaert D, Moskowitz MA, Fink JS, Schwarzschild MA |
| Source: JOURNAL OF NEUROSCIENCE Volume: 19 Issue: 21 Pages: 9192-9200 Published: NOV 1 1999 |
| Times Cited: 142 References: 53 |
| Abstract: Extracellular adenosine critically modulates ischemic brain injury, at least in part through activation of the A(1) adenosine receptor. However, the role played by the A(2A) receptor has been obscured by intrinsic limitations of A(2A) adenosinergic agents. To overcome these pharmacological limitations, we explored the consequences of deleting the A(2A) adenosine receptor on brain damage after transient focal ischemia. Cerebral morphology, as well as vascular and physiological measures (before, during, and after ischemia) did not differ between A(2A) receptor knock-out and wild-type littermates. The volume of cerebral infarction, as well as the associated neurological deficit induced by transient filament occlusion of the middle cerebral artery, were significantly attenuated in A(2A) receptor knock-out mice. This neuroprotective phenotype of A(2A) receptor-deficient mice was observed in different genetic backgrounds, confirming A(2A) receptor disruption as its cause. Together with complimentary pharmacological studies, these data suggest that A(2A) receptors play a prominent role in the development of ischemic injury within brain and demonstrate the potential for anatomical and functional neuroprotection against stroke by A(2A) receptor antagonists. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chen, JF (reprint author), Massachusetts Gen Hosp E, Mol Neurobiol Lab, 13th St, Charlestown, MA 02129 USA |
Addresses:
1. Massachusetts Gen Hosp, Dept Neurol & Neurosci, Mol Neurobiol Lab, Boston, MA 02114 USA
2. Massachusetts Gen Hosp, Dept Neurol & Neurosci, Stroke & Neurovasc Regulat Lab, Boston, MA 02114 USA
3. Massachusetts Gen Hosp, Dept Neurol & Neurosurg, Neurol Res Lab, Boston, MA 02114 USA
4. Harvard Univ, Sch Med, Boston, MA 02114 USA |
| Publisher: SOC NEUROSCIENCE, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA |
| Subject Category: Neurosciences |
| IDS Number: 246RG |
| ISSN: 0270-6474 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |