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| Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma |
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| Author(s): Arts HJG, Katsaros D, de Vries EGE, Massobrio M, Genta F, Danese S, Arisio R, Scheper RJ, Kool M, Scheffer GL, Willemse PHB, van der Zee AGJ, Suurmeijer AJH |
| Source: CLINICAL CANCER RESEARCH Volume: 5 Issue: 10 Pages: 2798-2805 Published: OCT 1999 |
| Times Cited: 60 References: 43 |
| Abstract: Intrinsic and/or acquired resistance to chemotherapy is the major obstacle to overcome in the treatment of patients with ovarian carcinoma. The aim of the present study was to investigate the prognostic value of drug resistance-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), canalicular multispecific organic anion transporter (c-MOAT/MRP2), and lung resistance protein (LRP) in ovarian carcinoma. Expression of P-gp, MRP1, MRP2, and LRP was determined by immunohistochemistry of frozen tissue sections of 115 ovarian carcinoma patients and related to clinicopathological factors, response to chemotherapy, and progression-free survival. P-gp expression was observed in 20 of 115 (17%), MRP1 in 51 (34%), MRP2 in 19 (16%), and LRP in 85 (74%) tumors. Expression of MRP1 was related to MRP2 (P < 0.0001) and P-gp (P < 0.001) expression, whereas LRP expression was more frequently observed in patients with early stage (P < 0.01), lower grade (P < 0.05), and smaller residual tumor (P < 0.05). Early stage (P < 0.001), smaller residual tumor (P < 0.001), and lower differentiation grade (P < 0.05) were related to longer (progression-free) survival. P-gp, MRP1, MRP2, and LRP expression were neither related to response to first-line chemotherapy In 59 evaluable patients nor to progression-free survival in all patients. On multivariate analysis, only stage and residual tumor were independent prognostic factors for survival. In conclusion, in ovarian carcinoma, MRP1 expression is associated with MRP2 and P-gp expression, whereas LRP expression is associated with favorable clinicopathological characteristics. Assessment of P-gp, MRP1, MRP2, or LRP does not allow prediction of response to chemotherapy or survival in ovarian carcinoma. |
| Document Type: Article |
| Language: English |
| Reprint Address: van der Zee, AGJ (reprint author), Univ Groningen Hosp, Dept Gynecol Oncol, POB 30-001, NL-9700 RB Groningen, Netherlands |
Addresses:
1. Univ Groningen Hosp, Dept Gynecol Oncol, NL-9700 RB Groningen, Netherlands
2. Univ Groningen Hosp, Dept Med Oncol, NL-9700 RB Groningen, Netherlands
3. Univ Groningen Hosp, Dept Pathol, NL-9700 RB Groningen, Netherlands
4. Univ Turin, SAnna Hosp, Dept Gynecol Gynecol Oncol, I-10126 Turin, Italy
5. Univ Turin, SAnna Hosp, Breast Canc Unit, I-10126 Turin, Italy
6. Univ Turin, SAnna Hosp, Dept Pathol, I-10126 Turin, Italy
7. Free Univ Amsterdam Hosp, Dept Pathol, NL-1081 HV Amsterdam, Netherlands
8. Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 248DD |
| ISSN: 1078-0432 |
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