| | |  | | | | Record from Web of Science® | | | | | | |
| Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan |
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| Author(s): The I, Bellaiche Y, Perrimon N |
| Source: MOLECULAR CELL Volume: 4 Issue: 4 Pages: 633-639 Published: OCT 1999 |
| Times Cited: 230 References: 51 |
| Abstract: Hedgehog (Hh) molecules play critical roles during development as a morphogen, and therefore their distribution must be regulated. Hh proteins undergo several modifications that tether them to the membrane. We have previously identified tout velu (ttv), a homolog of the mammalian EXT tumor supressor gene family, as a gene required for movement of Hh. In this paper, we present in vivo evidence that ttv is involved in heparan sulfate proteoglycan (HSPG) biosynthesis, suggesting that HSPGs control Hh distribution. In contrast to mutants in other HSPG biosynthesis genes, the activity of the HSPG-dependent FGF and Wingless signaling pathways are not affected in ttv mutants. This demonstrates an unexpected level of specificity in the regulation of the distribution of extracellular signals by HSPGs. |
| Document Type: Article |
| Language: English |
| Reprint Address: Perrimon, N (reprint author), Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 249WR |
| ISSN: 1097-2765 |
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