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| Regulation of lineage commitment distinct from positive selection |
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| Author(s): Keefe R, Dave V, Allman D, Wiest D, Kappes DJ |
| Source: SCIENCE Volume: 286 Issue: 5442 Pages: 1149-1153 Published: NOV 5 1999 |
| Times Cited: 44 References: 33 |
| Abstract: Developing alpha beta T cells diverge into the CD4 and CD8 Lineages as they mature in the thymus. It is unclear whether Lineage commitment is mechanistically distinct from the process that selects for the survival of T cells with useful T cell receptor (TCR) specificities (positive selection). In HD mice, which Lack mature CD4(+) T cells, major histocompatibility complex (MHC) class II-restricted T cells are redirected to the CD8 lineage independent of MHC class I expression. However, neither TCR-mediated signaling nor positive selection is impaired. Thus, the HD mutation provides genetic evidence that lineage commitment may be mechanistically distinct from positive selection. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kappes, DJ (reprint author), Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA |
Addresses:
1. Fox Chase Canc Ctr, Philadelphia, PA 19111 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 253AJ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |