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| Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia |
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| Author(s): Kodera Y, Morishima Y, Kato S, Akiyama Y, Sao H, Matsuyama T, Kawa K, Sakamaki H, Nakagawa S, Hirabayashi N, Dohi H, Okamoto S, Hiraoka A, Gondo H, Tsuchida M, O H, Harada M, Asano S, Juji T, Sasazuki T, Takaku F |
| Source: BONE MARROW TRANSPLANTATION Volume: 24 Issue: 9 Pages: 995-1003 Published: NOV 1999 |
| Times Cited: 50 References: 43 |
| Abstract: In December 1991, the Japan Marrow Donor Program (JMDP) was established with the cooperation of the Japanese Red Cross and Japan Marrow Donor Foundation under the auspices of the Ministry of Health and Welfare in Japan. By December 1998, 122365 HLA-A,B typed volunteer marrow donors and 7207 patients had been cumulatively registered in the JMDP. The results of HLA-matching between donors and patients revealed that 5684 out of 7207 (78.9%) patients could have at least one HLA-A,B,DR serologically matched donor, Among these matched pairs, 1829 unrelated bone marrow transplants (UR-BMT) were performed, The initial 500 UR-BMT transplanted fi om January 1993 to October 1995 were analyzed as of July 1998, Engraftment was achieved in 95% of cases. Probability of the occurrence of grade III and IV acute GVHD was 18.4%. The rate of disease-free survival (DFS) of the patients who had standard-risk leukemia and did not suffer from grade III or IV acute GVHD (n = 154) was 60-71% and the rate of survival of patients with aplastic anemia was 56%. It can be stated that UR-BMT is a modality of treatment which is as effective as related BMT if the occurrence of grade III or IV acute GVHD is predicted and prevented. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kodera, Y (reprint author), Japanese Red Cross Nagoya First Hosp, Dept Internal Med, Nakamura Ku, 3-35 Michishita Cho, Nagoya, Aichi 453 Japan |
Addresses:
1. Japanese Red Cross Nagoya First Hosp, Dept Internal Med, Nakamura Ku, Nagoya, Aichi 453 Japan
2. Aichi Canc Ctr, Dept Hematol & Chemotherapy, Aichi, Japan
3. Tokai Unvi Hosp, Dept Pediat, Tokai, Ibaraki Japan
4. Kyoto Univ Hosp, Dept Pediat, Kyoto 606, Japan
5. Japanese Red Cross Nagoya First Hosp, Dept Pediat, Nagoya, Aichi Japan
6. Osaka Med Ctr, Dept Pediat, Osaka, Japan
7. Tokyo Metropolitan Komagome Hosp, Dept Internal Med, Tokyo, Japan
8. Nagoya Daini Red Cross Hosp, Dept Internal Med, Nagoya, Aichi Japan
9. Hiroshima Red Cross Hosp, Dept Internal Med, Hiroshima, Japan
10. Atom Bomb Survivors Hosp, Fukuoka, Japan
11. Keio Univ, Sch Med, Dept Internal Med, Keio, Japan
12. Ctr Adult Dis, Dept Internal Med, Osaka 537, Japan
13. Kyushu Univ Hosp, Dept Internal Med 1, Fukuoka, Japan
14. Ibaraki Childrens Hosp, Dept Pediat, Ibaraki, Osaka Japan
15. Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 280, Japan
16. Okayama Univ Hosp, Dept Internal Med 2, Okayama, Japan
17. Univ Tokyo, Inst Med Sci, Dept Internal Med, Tokyo, Japan
18. Japanese Red Cross Cent Blood Ctr, Tokyo, Japan
19. Kyushu Univ, Med Inst Bioregulat, Fukuoka 812, Japan
20. Jichi Med Sch, Minami Kawachi, Tochigi Japan |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: 255HJ |
| ISSN: 0268-3369 |
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