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| 20q13.2 Amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast |
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| Author(s): Werner M, Mattis A, Aubele M, Cummings M, Zitzelsberger H, Hutzler P, Hofler H |
| Source: VIRCHOWS ARCHIV Volume: 435 Issue: 5 Pages: 469-472 Published: NOV 1999 |
| Times Cited: 31 References: 16 |
| Abstract: The 20q13 region harboring recently described putative oncogenes is frequently amplified in invasive ductal carcinoma (IDC). The aim of this study was to examine the 20q13 copy number in intraduct hyperplasia (IH), atypical duct hyperplasia (ADH), and ductal carcinoma in situ (DCIS) adjacent to IDC. In 5 patients, comparative genomic hybridization (CGH) after laser microdissection revealed 20q13 amplification in four of five cases of IH, in all of three cases of IH with atypia, all five of DCIS, and all five of IDC. Fluorescence in situ hybridization (FISH) confirmed the amplification at 20q13.2 in IH in the two specimens analyzed. The amplification rate, however, was higher in DCIS and IDC. In phenotypically normal ductal epithelium normal values were found for 20q13 copy number by FISH (n=2) and CGH (n=5). Although the number of cases presented here is small, our results suggest that mutations in the 20q13.2 region in IH may be associated with accelerated proliferation and hyperplasia of the ductal epithelium. Progression to DCIS and ICD is accompanied by a further increase in the 20q13.2 copy number. |
| Document Type: Article |
| Language: English |
| Reprint Address: Werner, M (reprint author), Tech Univ Munich, Klinikum Rechts Isar, Inst Allgemeine Pathol & Pathol Anat, Ismaninger Str 22, D-81675 Munich, Germany |
Addresses:
1. Tech Univ Munich, Klinikum Rechts Isar, Inst Allgemeine Pathol & Pathol Anat, D-81675 Munich, Germany
2. GSF, Natl Res Ctr Environm & Hlth, Inst Pathol, Neuherberg, Germany
3. Univ Queensland, Dept Pathol, St Lucia, Qld 4067 Australia
4. Univ Munich, Inst Radiobiol, Munich, Germany
5. GSF, Natl Res Ctr Environm & Hlth, Inst Radiobiol, Neuherberg, Germany |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 USA |
| Subject Category: Pathology |
| IDS Number: 261PJ |
| ISSN: 0945-6317 |
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