| | |  | | | | Record from Web of Science® | | | | | | |
| Serotonin transporter gene polymorphism and antidepressant response |
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| Author(s): Kim DK, Lim SW, Lee S, Sohn SE, Kim S, Hahn CG, Carroll BJ |
| Source: NEUROREPORT Volume: 11 Issue: 1 Pages: 215-219 Published: JAN 17 2000 |
| Times Cited: 209 References: 25 |
| Abstract: We examined allelic polymorphisms of the serotonin transporter (5-HTT) gene and antidepressant response to 6 weeks' treatment with the selective serotonin reuptake inhibitor (SSRI) drugs fluoxetine or paroxetine. We genotyped 120 patients and 252 normal controls, using polymerase chain reaction of genomic DNA with primers flanking the second intron and promoter regions of the 5-HTT gene. Diagnosis of depression was not associated with 5-HTT polymorphisms. Patients homozygous 1/1 in intron2 or homozygous sis in the promoter region showed better responses than all others (p<0.0001, p=0.0074, respectively). Lack of the 1/1 allele form in intron 2 most powerfully predicted non-response (83.3%). Response to SSRI drugs is related to allelic variation in the 5-HTT gene in depressed Korean patients. NeuroReport 11:215-219 (C) 2000 Lippincott Williams & Wilkins. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kim, DK (reprint author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat, 50 Ilwon Dong, Seoul 135710, South Korea |
Addresses:
1. Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat, Seoul 135710, South Korea
2. Samsung Biomed Res Inst, Clin Res Ctr, Seoul 135710, South Korea
3. MCPHU, Philadelphia, PA USA
4. Pacific Behav Res Fdn, Carmel, CA USA
5. Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Neurosciences |
| IDS Number: 274YA |
| ISSN: 0959-4965 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |