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| Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders |
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| Author(s): Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L |
| Source: SCIENCE Volume: 287 Issue: 5456 Pages: 1265-1269 Published: FEB 18 2000 |
| Times Cited: 766 References: 24 |
| Abstract: To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild-type human alpha-synuclein were generated. Neuronal expression of human alpha-synuclein resulted in progressive accumulation of alpha-synuclein-and ubiquitin-immunoreactive inclusions in neurons in the neocortex, hippocampus, and substantia nigra. Ultrastructural analysis revealed both electron-dense intranuclear deposits and cytoplasmic inclusions. These alterations were associated with Loss of dopaminergic terminals in the basal ganglia and with motor impairments. These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions. |
| Document Type: Article |
| Language: English |
| Reprint Address: Masliah, E (reprint author), Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA |
Addresses:
1. Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
2. Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
3. Yokohama City Univ, Sch Med, Dept Psychiat, Yokohama, Kanagawa 236 Japan
4. Univ Calif San Francisco, Gladstone Inst Neurol Dis, San Francisco, CA 94141 USA
5. Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94141 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 286KG |
| ISSN: 0036-8075 |
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