| Focal adhesions - the cytoskeletal connection |
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| Author(s): Critchley DR |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 12 Issue: 1 Pages: 133-139 Published: FEB 2000 |
| Times Cited: 318 References: 56 |
| Abstract: Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic, biochemical and structural data have highlighted the role played by a subset of actin-binding proteins in coupling integrins to cytoskeletal actin and in assembling signalling complexes that are important for cell motility and cell proliferation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Critchley, DR (reprint author), Univ Leicester, Dept Biochem, Univ Rd, Leicester LE1 7RH, Leics England |
Addresses:
1. Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics England |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 286XY |
| ISSN: 0955-0674 |