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| Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis |
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| Author(s): Kaya M, Wada T, Akatsuka T, Kawaguchi S, Nagoya S, Shindoh M, Higashino F, Mezawa F, Okada F, Ishii S |
| Source: CLINICAL CANCER RESEARCH Volume: 6 Issue: 2 Pages: 572-577 Published: FEB 2000 |
| Times Cited: 77 References: 28 |
| Abstract: To investigate the clinical significance of vascular endothelial growth factor (VEGF) in osteosarcoma, He immunohistochemically stained biopsy specimens of 27 primary osteosarcomas using an antibody against VEGF and evaluated the correlation between the expression of VEGF and local density of CD34-positive microvessels, clinicopathological variables, and survival of patients. VEGF staining was positive in 17 tumors (63.0%) in which the density of CD34-positive microvessels was significantly higher than that in VEGF-negative 10 tumors (P < 0.05), In terms of clinicopathological variables, there was no correlation between the expression of VEGF and histological subtype, stage, or response to neoadjuvant chemotherapy, or, strikingly, to the development of pulmonary metastasis (89% of VEGF-positive tumors versus 10% of VEGF-negative tumors; P < 0.0003), Moreover, patients with a VEGF-positive tumor were poorer in both disease-free survival (P < 0.001) and overall survival (P < 0.03) compared to those with a VEGF-negative tumor. These findings strongly suggest that VEGF expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis in patients who underwent aggressive therapy and also provide the basis for a therapeutic strategy targeting angiogeneic property of osteosarcoma. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kaya, M (reprint author), Sapporo Med Univ, Sch Med, Dept Orthoped Surg, Chuo Ku, S-1,W-16, Sapporo, Hokkaido 0608543 Japan |
Addresses:
1. Sapporo Med Univ, Sch Med, Dept Orthoped Surg, Chuo Ku, Sapporo, Hokkaido 0608543 Japan
2. Hokkaido Univ, Dept Oral Pathol, Sch Dent, Sapporo, Hokkaido 0608586 Japan
3. Hokkaido Univ, Sch Med, Inst Canc, Pathol Lab, Sapporo, Hokkaido 0608638 Japan |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 287JK |
| ISSN: 1078-0432 |
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