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| Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer |
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| Author(s): Jonsson M, Borg A, Nilbert M, Andersson T |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 36 Issue: 2 Pages: 242-248 Published: JAN 2000 |
| Times Cited: 37 References: 31 |
| Abstract: We studied the relevance of adenomatous polyposis coli (APC)/beta-catenin signalling in the development of breast cancer by analysing the expression of beta-catenin in 54 primary breast tumours (34 ductal and 20 lobular). We showed that 13% of the tumours exhibited upregulated levels of beta-catenin in the cytosol suggesting that defects in APC, beta-catenin signalling components had lowered the rate of beta-catenin degradation. No mutations were observed in the amino-terminal region of beta-catenin which comprises conserved serine residues important for phosphorylation-dependent degradation of the protein, but the APC protein was altered in 6% of the tumours. Tyrosine phosphorylation of beta-catenin was detected in only one tumour and could, therefore not have been responsible for the observed increased levels of this protein. Although 9% of the tumours displayed upregulation of c-MYC protein, there was no correlation with beta-catenin overexpression. suggesting that increased beta-catenin expression is not the major cause of c-myc gene activation in breast cancer. It is imperative that elements that selectively drive the oncogenic activity of beta-catenin in breast cancer be identified. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Jonsson, M (reprint author), Univ Lund, Malmo Univ Hosp, Div Expt Pathol, SE-20502 Malmo, Sweden |
Addresses:
1. Univ Lund, Malmo Univ Hosp, Div Expt Pathol, SE-20502 Malmo, Sweden
2. Univ Lund Hosp, Jubileum Inst, Dept Oncol, SE-22185 Lund, Sweden |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 288ED |
| ISSN: 0959-8049 |
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