| | |  | | | | Record from Web of Science® | | | | | | |
| Solid-pseudopapillary tumor of the pancreas: A typically cystic carcinoma of low malignant potential |
|
|
| Author(s): Klimstra DS, Wenig BM, Heffess CS |
| Source: SEMINARS IN DIAGNOSTIC PATHOLOGY Volume: 17 Issue: 1 Pages: 66-80 Published: FEB 2000 |
| Times Cited: 106 References: 69 |
| Abstract: Solid-pseudopapillary tumors are uncommon neoplasms of low malignant potential generally occurring in young women. They often cause few symptoms and may reach a large size by the time they are detected, Degenerative cystic changes are common, and the clinical presentation is often that of a cystic pancreatic tumor. Pathological features include solid, cellular, hypervascular regions without gland formation, and degenerative pseudopapillae. The cells contain eosinophilic granules rich in alpha-1-antitrypsin and the nuclei are typically grooved. Despite its characteristic microscopic appearance, the immunophenotype (positive for vimentin, alpha-1-antitrypsin, and neuron specific enolase) Is nor specific and does not define a line of differentiation corresponding to any normal pancreatic cell type. Ultrastructural studies have also failed to identify specific differentiated features. Nonetheless, the biological behavior of solid-pseudopapillary tumor is well established. The tumor is indolent, with infrequent metastases to liver or peritoneum and usually long survival, even in the presence of disseminated disease. Copyright (C) 2000 by W.B. Saunders Company. |
| Document Type: Article |
| Language: English |
| Reprint Address: Klimstra, DS (reprint author), Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA |
Addresses:
1. Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
2. Albert Einstein Univ, Sch Med, Montefiore Med Ctr, New York, NY USA
3. Armed Forces Inst Pathol, Dept Endocrine, Washington, DC 20306 USA
4. Armed Forces Inst Pathol, Dept Otorhinolaryng Head & Neck Pathol, Washington, DC 20306 USA |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Medical Laboratory Technology; Pathology |
| IDS Number: 293GD |
| ISSN: 0740-2570 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |