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| Ca2+-dependent gene expression mediated by MEF2 transcription factors |
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| Author(s): Blaeser F, Ho N, Prywes R, Chatila TA |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 275 Issue: 1 Pages: 197-209 Published: JAN 7 2000 |
| Times Cited: 105 References: 56 |
| Abstract: Ca2+ induction of a subset of cellular and viral immediate-early activation genes in lymphocytes has been previously mapped to response elements recognized by the MEF2 family of transcription factors. Here, we demonstrate that Ca2+ activation of MEF2 response elements in T lymphocytes is mediated in synergy by two Ca2+/calmodulin-dependent enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up-regulates the activity of both factors by an NFAT-dependent mechanism, while CaMKIV/Gr selectively and independently activates MEF2D. These results identify MEF2 proteins as effecters of a pathway of gene induction in T lymphocytes which integrates diverse Ca2+ activation signals and may be broadly operative in several tissues. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chatila, TA (reprint author), Washington Univ, Sch Med, Dept Pediat, Div Immunol Rheumatol, 1 Childrens Pl, St Louis, MO 63110 USA |
Addresses:
1. Washington Univ, Sch Med, Dept Pediat, Div Immunol Rheumatol, St Louis, MO 63110 USA
2. Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
3. Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
4. Columbia Univ, Dept Biol Sci, New York, NY 10027 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 295DN |
| ISSN: 0021-9258 |
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