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| Comparative genomics of the eukaryotes |
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| Author(s): Rubin GM, Yandell MD, Wortman JR, Miklos GLG, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LSB, Gong FC, Guan P, Harris NL, Hay BA, Hoskins RA, Li JY, Li ZY, Hynes RO, Jones SJM, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XQH, Zhong F, Zhong WY, Gibbs R, Venter JC, Adams MD, Lewis S |
| Source: SCIENCE Volume: 287 Issue: 5461 Pages: 2204-2215 Published: MAR 24 2000 |
| Times Cited: 866 References: 84 |
| Abstract: A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease. |
| Document Type: Review |
| Language: English |
| Reprint Address: Rubin, GM (reprint author), Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA |
Addresses:
1. Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
2. Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA
3. Celera Genom, Rockville, MD 20850 USA
4. Genetixxpress, Sydney, NSW 2108 Australia
5. Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
6. Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
7. EMBL, EBI, Cambridge CB10 1SD, England
8. Stanford Univ, Dept Genet, Stanford, CA 94305 USA
9. Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA
10. Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
11. NINDS, Neurogenet Unit, Neurochem Lab, NIH, Bethesda, MD 20892 USA
12. Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA
13. Neomorphic, Berkeley, CA 94710 USA
14. Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire England
15. Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
16. Univ Calif San Diego, Howard Hughes Med Inst, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
17. Univ Calif San Diego, Howard Hughes Med Inst, Dept Pharmacol, La Jolla, CA 92093 USA
18. CALTECH, Div Biol, Pasadena, CA 91125 USA
19. MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
20. BC Canc Res Ctr, Genome Sequence Ctr, Vancouver, BC V52 4E6 Canada
21. Univ Maryland, Cell & Mol Biol Program, Baltimore, MD 21201 USA
22. CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France
23. MIT, Ctr Learning & Memory, Cambridge, MA 02139 USA
24. NCI, Regulat Cell Growth Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr,NIH, Ft Detrick, MD 21702 USA
25. Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
26. Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA
27. Baylor Coll Med, Human Genome Sequencing Ctr, Dept Mol & Human Genet, Houston, TX 77030 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 296WE |
| ISSN: 0036-8075 |
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