| | |  | | | | Record from Web of Science® | | | | | | |
| From sequence to chromosome: The tip of the X chromosome of D. melanogaster |
|
|
| Author(s): Benos PV, Gatt MK, Ashburner M, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demailles J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Minana B, Kafatos FC, Louis C, Siden-Kiamos I, Bolshakov S, Papagiannakis G, Spanos L, Cox S, Madueno E, de Pablos B, Modolell J, Peter A, Schottler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schafer U, Jackle H, Bucheton A, Callister DM, Campbell LA, Darlamitsou A, Henderson NS, McMillan PJ, Salles C, Tait EA, Valenti P, Saunders RDC, Glover DM |
| Source: SCIENCE Volume: 287 Issue: 5461 Pages: 2220-2222 Published: MAR 24 2000 |
| Times Cited: 19 References: 32 |
| Abstract: One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a Long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Benos, PV (reprint author), European Bioinformat Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England |
Addresses:
1. European Bioinformat Inst, Cambridge CB10 1SD, England
2. Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
3. Sanger Ctr, Cambridge CB10 1SA, England
4. Univ Montpellier, Sch Med, IGH, CNRS, F-34396 Montpellier 5, France
5. Fac Med, CNRS, Unite Propre Rech 41, F-35043 Rennes, France
6. European Mol Biol Lab, Heidelberg, Germany
7. Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Heraklion, Greece
8. Univ Crete, Dept Biol, Heraklion, Greece
9. Univ Autonoma Madrid, E-28049 Madrid, Spain
10. CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
11. Max Planck Inst Biophys Chem, Dept Mol Dev Biol, D-37070 Gottingen, Germany
12. Univ Dundee, Dept Anat & Physiol, Canc Res Campaign, Cell Cycle Genet Grp, Dundee DD1 4HN, Scotland
13. Open Univ, Dept Biol Sci, Milton Keynes MK7 6AA, Bucks England |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 296WE |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |