| | |  | | | | Record from Web of Science® | | | | | | |
| A Drosophila model of Parkinson's disease |
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| Author(s): Feany MB, Bender WW |
| Source: NATURE Volume: 404 Issue: 6776 Pages: 394-398 Published: MAR 23 2000 |
| Times Cited: 754 References: 30 |
| Abstract: Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease(1,2) and alpha-synuclein accumulates in Lewy bodies and Lewy neurites(3-5). Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: Feany, MB (reprint author), Brigham & Womens Hosp, Dept Pathol, Div Neuropathol, 75 Francis St, Boston, MA 02115 USA |
Addresses:
1. Brigham & Womens Hosp, Dept Pathol, Div Neuropathol, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 298BG |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |