| | |  | | | | Record from Web of Science® | | | | | | |
| Functions of the nuclear lamins |
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| Author(s): Vaughan OA, Whitfield WGF, Hutchison CJ |
| Source: PROTOPLASMA Volume: 211 Issue: 1-2 Pages: 1-7 Published: 2000 |
| Times Cited: 5 References: 48 |
| Abstract: The nuclear lamina is a filamentous structure, composed of lamins, that supports the inner nuclear membrane. Several integral membrane proteins including LBR (lamin B receptor), LAP (lamin-associated polypeptide) 1, and LAP 2 bind nuclear lamins in vitro and may influence lamin function and dynamics in vivo. Results from various studies suggest that lamins may have major functions in DNA replication, nuclear-envelope assembly, and nuclear-envelope growth. Here we discuss experimental evidence that supports these hypotheses and consider how interactions between lamins and other nuclear-envelope proteins, in particular LBR and LAP2 isoforms, may contribute to or alternatively mediate these functions of the lamina. |
| Document Type: Article |
| Language: English |
| Reprint Address: Vaughan, OA (reprint author), Univ Durham, Dept Biol Sci, Mountjoy Sci Pk, Durham DH1 3HP, England |
Addresses:
1. Univ Dundee, Dept Biol Sci, Dundee DD1 4HN, Scotland |
| Publisher: SPRINGER-VERLAG WIEN, SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA |
| Subject Category: Plant Sciences; Cell Biology |
| IDS Number: 301VX |
| ISSN: 0033-183X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |