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Optical coherence tomography: An emerging technology for biomedical imaging and optical biopsy
Author(s): Fujimoto JG, Pitris C, Boppart SA, Brezinski ME
Source: NEOPLASIA    Volume: 2    Issue: 1-2    Pages: 9-25    Published: JAN-APR 2000  
Times Cited: 147     References: 86     
Abstract: Optical coherence tomography (OCT) is an emerging technology for performing high-resolution cross-sectional imaging. OCT is analogous to ultrasound imaging, except that it uses light instead of sound. OCT can provide cross-sectional images of tissue structure on the micron scale in situ and in real time. Using OCT in combination with catheters and endoscopes enables high-resolution intraluminal imaging of organ systems. OCT can function as a type of optical biopsy and is a powerful imaging technology for medical diagnostics because unlike conventional histopathology which requires removal of a tissue specimen and processing for microscopic examination, OCT can provide images of tissue in situ and in real time. OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisional biopsy, and to guide interventional procedures. in this paper, we review OCT technology and describe its potential biomedical and clinical applications.
Document Type: Review
Language: English
Reprint Address: Fujimoto, JG (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA
Addresses:
1. MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
2. MIT, Elect Res Lab, Cambridge, MA 02139 USA
3. Harvard Univ, Sch Med, Div Hlth Sci & Technol, Boston, MA USA
4. Harvard Univ, Sch Med, Dept Med, Boston, MA USA
5. Harvard Univ, Sch Med, Cardiac Unit, Boston, MA USA
6. Massachusetts Gen Hosp, Boston, MA 02114 USA
Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA
Subject Category: Oncology
IDS Number: 305BV
ISSN: 1522-8002
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