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| Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas |
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| Author(s): Arlotta P, Tai AKF, Manfioletti G, Clifford C, Jay G, Ono SJ |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 275 Issue: 19 Pages: 14394-14400 Published: MAY 12 2000 |
| Times Cited: 62 References: 49 |
| Abstract: Chromosomal translocations in human lipomas frequently create fusion transcripts encoding high mobility group (HMG) I-C DNA-binding domains and C-terminal sequences from different presumed transcription factors, suggesting a potential role for HMG I-C in the development of lipomas. To evaluate the role of the HMG I-C component, the three DNA-binding domains of HMG I-C have now been expressed in transgenic mice. Despite the ubiquitous expression of the truncated HMG I-C protein, the transgenic mice develop a selective abundance of fat tissue early in life, show marked adipose tissue inflammation, and have an abnormally high incidence of lipomas. These findings demonstrate that the DNA-binding domains of HMG I-C, in the absence of a C-terminal fusion partner, are sufficient to perturb adipogenesis and predispose to lipomas. We provide data supporting the central utility of this animal model as a tool to understand the molecular mechanisms underlying the development of one of the most common kind of human benign tumors. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ono, SJ (reprint author), Harvard Univ, Sch Med, Schepens Eye Res Inst, Comm Immunol, 20 Staniford St, Boston, MA 02114 USA |
Addresses:
1. Harvard Univ, Sch Med, Schepens Eye Res Inst, Comm Immunol, Boston, MA 02114 USA
2. Brigham & Womens Hosp, Dept Med, Div Rheumatol Allergy & Immunol, Schepens Eye Res Inst, Boston, MA 02114 USA
3. Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy
4. Charles River Labs, Dept Pathol, Wilmington, MA 01887 USA
5. OriGene Technol Inc, Rockville, MD 20850 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 313NZ |
| ISSN: 0021-9258 |
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