| | |  | | | | Record from Web of Science® | | | | | | |
| Acetylation and chromosomal functions |
|
|
| Author(s): Cheung WL, Briggs SD, Allis CD |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 12 Issue: 3 Pages: 326-333 Published: JUN 2000 |
| Times Cited: 178 References: 71 |
| Abstract: Since the initial discovery of histone acetyltransferases, numerous reports have established that histone acetyltransferases and histone deacetylases regulate transcription by acetylating and deacetylating histones, respectively Recent studies have focused on the effects of histone acetylation on gene expression regulation during development and the roles of histone hypoacetylation in the maintenance of centromeric structure, X-inactivation and genomic imprinting. Recent findings have also shown that the functions of non-histone proteins can also be regulated by acetylation. Together, these data highlight the importance of acetylation of histones and non-histone proteins in a variety of chromosomal functions. |
| Document Type: Review |
| Language: English |
| Reprint Address: Cheung, WL (reprint author), Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Box 800733 Jordan Hall,Rm 6222, Charlottesville, VA 22908 USA |
Addresses:
1. Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA
2. Univ Virginia, Hlth Sci Ctr, Dept Mol Genet & Biochem, Charlottesville, VA 22908 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 315XL |
| ISSN: 0955-0674 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |