| | |  | | | | Record from Web of Science® | | | | | | |
| Generalized potential of adult neural stem cells |
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| Author(s): Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlstrom H, Lendahl U, Frisen J |
| Source: SCIENCE Volume: 288 Issue: 5471 Pages: 1660-1663 Published: JUN 2 2000 |
| Times Cited: 587 References: 25 |
| Abstract: The differentiation potential of stem ce(Ls in tissues of the adult has been thought to be Limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases. |
| Document Type: Article |
| Language: English |
| Reprint Address: Frisen, J (reprint author), Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden |
Addresses:
1. Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
2. Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 320BZ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |