| | |  | | | | Record from Web of Science® | | | | | | |
| Autoimmune disease in first-degree relatives of patients with multiple sclerosis - A UK survey |
|
|
| Author(s): Broadley SA, Deans J, Sawcer SJ, Clayton D, Compston DAS |
| Source: BRAIN Volume: 123 Pages: 1102-1111 Part: Part 6 Published: JUN 2000 |
| Times Cited: 82 References: 58 |
| Abstract: Previous studies examining an association with other autoimmune diseases have suggested the existence of a generalized autoimmune diathesis in patients with multiple sclerosis. We investigated the prevalence of autoimmune disease in first-degree relatives of probands with multiple sclerosis using a case-control method. The results show an excess of autoimmune disease within these families, but no significant association was seen with nonautoimmune diseases. The higher risk in multiplex than simplex families suggests an effect of genetic loading. While the increase in risk applies to each autoimmune disease, autoimmune thyroid disease (and Graves' disease in particular) contributes disproportionately to the excess risk, There was no increase in autoimmune disease within patients with multiple sclerosis themselves when compared with the index controls or population data, We conclude that autoimmune disease is more common in first-degree relatives of patients with multiple sclerosis and hypothesize that common genetic susceptibility factors for autoimmunity co-exist with additional disease specific genetic or environmental factors, which determine clinical phenotype in the individual. |
| Document Type: Article |
| Language: English |
| Reprint Address: Compston, DAS (reprint author), Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Hills Rd, Cambridge CB2 2QQ, England |
Addresses:
1. Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England
2. Inst Publ Hlth, MRC, Biostat Unit, Cambridge, England |
| Publisher: OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND |
| Subject Category: Clinical Neurology; Neurosciences |
| IDS Number: 324BZ |
| ISSN: 0006-8950 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |