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| The genetics of human tooth agenesis: New discoveries for understanding dental anomalies |
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| Author(s): Vastardis H |
| Source: AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS Volume: 117 Issue: 6 Pages: 650-656 Published: JUN 2000 |
| Times Cited: 75 References: 85 |
| Abstract: The important role of genetics has been increasingly recognized in recent years with respect to the understanding of dental anomalies, such as tooth agenesis, The lack of any real insight into the cause of this condition has led us to use a human molecular genetics approach to identify the genes perturbing normal dental development. We are reporting a strategy that can be applied to investigate the underlying cause of human tooth agenesis, Starting with a single large family presenting a clearly recognizable and well-defined form of tooth agenesis, we have identified a defective gene that affects the formation of second premolars and third molars, With the use of " the family study" method, evidence is produced showing that other genetic defects also contribute to the wide range of phenotypic variability of tooth agenesis. Identification of genetic mutations in families with tooth agenesis or other dental anomalies will enable preclinical diagnosis and permit improved orthodontic treatment. |
| Document Type: Article |
| Language: English |
| Reprint Address: Vastardis, H (reprint author), NYU, Coll Dent, Div Growth & Dev Sci Orthodont, Div Basic Sci, 345 E 24th St, New York, NY 10010 USA |
Addresses:
1. NYU, Coll Dent, Div Growth & Dev Sci Orthodont, Div Basic Sci, New York, NY 10010 USA
2. Harvard Sch Dent Med, New York, NY USA |
| Publisher: MOSBY-YEAR BOOK INC, 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA |
| Subject Category: Dentistry, Oral Surgery & Medicine |
| IDS Number: 324NQ |
| ISSN: 0889-5406 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |