| | |  | | | | Record from Web of Science® | | | | | | |
| Neurotrophin signal transduction in the nervous system |
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| Author(s): Kaplan DR, Miller FD |
| Source: CURRENT OPINION IN NEUROBIOLOGY Volume: 10 Issue: 3 Pages: 381-391 Published: JUN 2000 |
| Times Cited: 875 References: 122 |
| Abstract: Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappa B signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals. |
| Document Type: Review |
| Language: English |
| Reprint Address: Kaplan, DR (reprint author), McGill Univ, Montreal Neurol Inst, Brain Tumor Res Ctr, 3801 Univ St, Montreal, PQ H3A 2B4 Canada |
Addresses:
1. McGill Univ, Montreal Neurol Inst, Brain Tumor Res Ctr, Montreal, PQ H3A 2B4 Canada
2. McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A 2B4 Canada |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: 327MQ |
| ISSN: 0959-4388 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |