| | |  | | | | Record from Web of Science® | | | | | | |
| The biology of multiple myeloma |
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| Author(s): Drach J, Kaufmann H, Urbauer E, Schreiber S, Ackermann J, Huber H |
| Source: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY Volume: 126 Issue: 8 Pages: 441-447 Published: AUG 2000 |
| Times Cited: 23 References: 64 |
| Abstract: Multiple myeloma (MM) is a B-cell malignancy originating from pre-switched. follicle center B-lymphocytes which differentiate to plasma cells accumulating in the bone marrow. MM cells are characterized by a profound genetic instability resulting in a complex set of numerical and structural chromosomal abnormalities. Among these abnormalities, translocations involving 14q32. the immunoglobulin heavy-chain locus, are the most frequent aberrations, but translocation partners are remarkably heterogeneous. Chromosome 13q14 may harbor a critical tumor suppressor gene since MM patients with deletion of 13q14 experience short overall survival after conventional-dose and high-dose chemotherapy. Bone marrow stroma cells support growth and survival of MM cells, which in turn influence the bone marrow microenvironment. This is particularly evident by the markedly increased bone man ow vascularization observed in most patients with active MM. |
| Document Type: Review |
| Language: English |
| Reprint Address: Drach, J (reprint author), Univ Vienna, Dept Internal Med 1, Div Clin Oncol, Waehringer Gurtel 18-20, A-1090 Vienna, Austria |
Addresses:
1. Univ Vienna, Dept Internal Med 1, Div Clin Oncol, A-1090 Vienna, Austria |
| Publisher: SPRINGER-VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 USA |
| Subject Category: Oncology |
| IDS Number: 339DD |
| ISSN: 0171-5216 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |