| | |  | | | | Record from Web of Science® | | | | | | |
| Serine proteases and brain damage - is there a link? |
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| Author(s): Gingrich MB, Traynelis SF |
| Source: TRENDS IN NEUROSCIENCES Volume: 23 Issue: 9 Pages: 399-407 Published: SEP 2000 |
| Times Cited: 119 References: 119 |
| Abstract: The protective blood-brain barrier normally allows diffusion of small molecules such as oxygen and carbon dioxide, and transport of essential nutrients, but excludes large proteins and other blood constituents from the interstitial space of the CNS. However, head trauma, stroke, status epilepticus and other pathological conditions can all compromise the integrity of this barrier, and allow blood proteins as large as albumin to gain access to the extracellular spaces that surround neurons and glia. Given their possible entry into brain tissue during cerebrovascular insult, the effects of blood-derived proteases such as thrombin, tissue plasminogen activator and plasmin in the CNS have come under increasing scrutiny. Evidence now supports a role for serine proteases in the sequence of events that can lead to glial scarring, edema, seizure and neuronal death. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Gingrich, MB (reprint author), Univ Virginia, Ctr Reprod, Charlottesville, VA 22908 USA |
Addresses:
1. Univ Virginia, Ctr Reprod, Charlottesville, VA 22908 USA
2. Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: 350AD |
| ISSN: 0166-2236 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |