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| HLA in alopecia areata |
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| Author(s): Kavak A, Baykal C, Ozarmagan G, Akar U |
| Source: INTERNATIONAL JOURNAL OF DERMATOLOGY Volume: 39 Issue: 8 Pages: 589-592 Published: AUG 2000 |
| Times Cited: 18 References: 18 |
| Abstract: Background The aim of this study was to investigate the human leukocyte antigen (HLA) characteristics of Turkish alopecia areata patients, and the correlation of the HLA profile with age of onset, severity and duration of the disease, presence of ophiasis, and family history. Methods A total of 88 patients with alopecia areata, alopecia totalis, or alopecia universalis were compared with 100 healthy controls. HLA typing was performed by the Terasaki microlymphocytotoxicity method.
Results The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HL4-DQ3 was significantly higher in patients than in controls. HL4-DR16 was significantly less common in patients than in the control group, and we concluded that this allele might have a protective role for alopecia areata. Juvenile onset and severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA profile was independent of the existence of long-standing disease, presence of ophiasis, and a positive family history.
Conclusions In HLA-alopecia areata association, ethnic differences may play a role.
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| Document Type: Article |
| Language: English |
| Reprint Address: Kavak, A (reprint author), Abant Izzet Baysal Univ, Duzce Hosp, Dept Dermatol, Duzce Bolu, Turkey |
Addresses:
1. Istanbul Univ, Fac Med, Dept Dermatol, Istanbul, Turkey
2. Istanbul Univ, Fac Med, Dept Med Biol, Istanbul, Turkey |
| Publisher: BLACKWELL SCIENCE LTD, P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND |
| Subject Category: Dermatology |
| IDS Number: 351KT |
| ISSN: 0011-9059 |
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