| | |  | | | | Record from Web of Science® | | | | | | |
| Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-l |
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| Author(s): Jochum W, David JP, Elliott C, Wutz A, Plenk H, Matsuo K, Wagner EF |
| Source: NATURE MEDICINE Volume: 6 Issue: 9 Pages: 980-984 Published: SEP 2000 |
| Times Cited: 150 References: 30 |
| Abstract: Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions. |
| Document Type: Article |
| Language: English |
| Reprint Address: Wagner, EF (reprint author), Res Inst Mol Pathol, Dr Bohr Gasse 7, A-1030 Vienna, Austria |
Addresses:
1. Res Inst Mol Pathol, A-1030 Vienna, Austria
2. Univ Vienna, Inst Histol & Embryol Bone & Biomat Res, A-1090 Vienna, Austria |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 351ZR |
| ISSN: 1078-8956 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |