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| Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae |
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| Author(s): Lin SJ, Defossez PA, Guarente L |
| Source: SCIENCE Volume: 289 Issue: 5487 Pages: 2126-2128 Published: SEP 22 2000 |
| Times Cited: 559 References: 24 |
| Abstract: Calorie restriction extends Life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration. the mechanism by which this regimen slows aging is uncertain. Here, we mimicked calorie restriction in yeast by physiological or genetic means and showed a substantial extension in Life-span. This extension was not observed in strains mutant for SIR2 (which encodes the silencing protein Sir2p) or NPT1 (a gene in a pathway in the synthesis of NAD, the oxidized form of nicotinamide adenine dinucleotide), These findings suggest that the increased longevity induced by calorie restriction requires the activation of Sir2p by NAD. |
| Document Type: Article |
| Language: English |
| Reprint Address: Guarente, L (reprint author), MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Dept Biol, Cambridge, MA 02139 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 356EG |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |