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| High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients |
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| Author(s): Oksenhendler E, Carcelain G, Aoki Y, Boulanger E, Maillard A, Clauvel JP, Agbalika F |
| Source: BLOOD Volume: 96 Issue: 6 Pages: 2069-2073 Published: SEP 15 2000 |
| Times Cited: 112 References: 27 |
| Abstract: Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency Virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-induced clinical re mission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder. (Blood. 2000;96:2069-2073) (C) 2000 by The American Society of Hematology. |
| Document Type: Article |
| Language: English |
| Reprint Address: Oksenhendler, E (reprint author), Hop St Louis, Serv Immunohematol, Dept Immunol & Hematol, Virol Lab, 1 Ave Claude Vellefaux, F-75010 Paris, France |
Addresses:
1. Hop St Louis, Serv Immunohematol, Dept Immunol & Hematol, Virol Lab, F-75010 Paris, France
2. Hop La Pitie Salpetriere, Immunol Lab, Paris, France
3. NCI, Med Branch, NIH, Bethesda, MD 20892 USA |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 358VN |
| ISSN: 0006-4971 |
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