| | |  | | | | Record from Web of Science® | | | | | | |
| Resetting of circadian time peripheral tissues by glucocorticoid signaling |
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| Author(s): Balsalobre A, Brown SA, Marcacci L, Tronche F, Kellendonk C, Reichardt HM, Schutz G, Schibler U |
| Source: SCIENCE Volume: 289 Issue: 5488 Pages: 2344-2347 Published: SEP 29 2000 |
| Times Cited: 392 References: 21 |
| Abstract: In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day. |
| Document Type: Article |
| Language: English |
| Reprint Address: Schibler, U (reprint author), Univ Geneva, Dept Biol Mol Sci 2, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland |
Addresses:
1. Univ Geneva, Dept Biol Mol Sci 2, CH-1211 Geneva, Switzerland
2. Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 359CG |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |