| | |  | | | | Record from Web of Science® | | | | | | |
| Purified hematopoietic stem cells can differentiate into hepatocytes in vivo |
|
|
| Author(s): Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M |
| Source: NATURE MEDICINE Volume: 6 Issue: 11 Pages: 1229-1234 Published: NOV 2000 |
| Times Cited: 1,303 References: 48 |
| Abstract: The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH(-/-) mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lagasse, E (reprint author), StemCells, 525 Del Rey Ave,Suite C, Sunnyvale, CA 94085 USA |
Addresses:
1. StemCells, Sunnyvale, CA 94085 USA
2. Oregon Hlth Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA
3. Texas Childrens Hosp, Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
4. Stanford Univ, Sch Med, Dept Pathol & Dev Biol, Stanford, CA 94305 USA |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 370GH |
| ISSN: 1078-8956 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |