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| MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study |
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| Author(s): Cuthbert G, Thompson K, McCullough S, Watmore A, Dickinson H, Telford N, Mugneret F, Harrison C, Griffiths M, Bown N |
| Source: LEUKEMIA Volume: 14 Issue: 11 Pages: 1885-1891 Published: NOV 2000 |
| Times Cited: 26 References: 33 |
| Abstract: The MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cuthbert, G (reprint author), Newcastle Univ, Sch Biochem & Genet, Dept Cytogenet, 3rd Floor,Ridley Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear England |
Addresses:
1. Newcastle Univ, Sch Biochem & Genet, Dept Cytogenet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear England
2. Sheffield Childrens Hosp NHS Trust, N Trent Cytogenet Serv, Sheffield, S Yorkshire England
3. St James Univ Hosp, Dept Clin Genet, Yorkshire Reg Genet Serv, Leeds, W Yorkshire England
4. Christie Hosp NHS Trust, Oncol Cytogenet Serv, Manchester M20 4BX, Lancs England
5. CHU Bocage, Lab Cytogenet, Dijon, France
6. UCL Royal Free & Univ Coll, Sch Med, Dept Haematol, Cytogenet Lab, London, England
7. Birmingham Womens Hosp, Reg Genet Lab, Birmingham, W Midlands England |
| Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Oncology; Hematology |
| IDS Number: 370LU |
| ISSN: 0887-6924 |
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