| | |  | | | | Record from Web of Science® | | | | | | |
| Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation |
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| Author(s): Crosby JR, Kaminski WE, Schatteman G, Martin PJ, Raines EW, Seifert RA, Bowen-Pope DF |
| Source: CIRCULATION RESEARCH Volume: 87 Issue: 9 Pages: 728-730 Published: OCT 27 2000 |
| Times Cited: 240 References: 11 |
| Abstract: Granulation tissue formation is an example of new tissue development in an adult. its rich vascular network has been thought to derive via angiogenic sprouting and extension of preexisting vessels from the surrounding tissue. The possibility that circulating cells of hematopoietic origin can differentiate into vascular endothelial cells (ECs) in areas of vascular remodeling has recently gained credibility. However, no quantitative data have placed the magnitude of this contribution into a physiological perspective. We have used hematopoietic chimeras to determine that 0.2% to 1.4% of ECs in vessels in control tissues derived from hematopoietic progenitors during the 4 months after irradiation and hematopoietic recovery. By contrast, 8.3% to 11.2% of ECs in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulating hematopoietic progenitors. This recruitment of circulating progenitors to newly forming vessels would be difficult to observe in standard histological studies, but it is large enough to be encouraging for attempts to manipulate this contribution for therapeutic gain. |
| Document Type: Article |
| Language: English |
| Reprint Address: Bowen-Pope, DF (reprint author), Univ Washington, Hlth Sci Ctr, Dept Pathol, Box 357470,Room D525, Seattle, WA 98195 USA |
Addresses:
1. Univ Washington, Hlth Sci Ctr, Dept Pathol, Seattle, WA 98195 USA
2. Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease |
| IDS Number: 372DJ |
| ISSN: 0009-7330 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |