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| Report of an international working group to standardize response criteria for myelodysplastic syndromes |
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| Author(s): Cheson BD, Bennett JM, Kantarjian H, Pinto A, Schiffer CA, Nimer SD, Lowenberg B, Beran M, de Witte TM, Stone RM, Mittelman M, Sanz GF, Wijermans PW, Gore S, Greenberg PL |
| Source: BLOOD Volume: 96 Issue: 12 Pages: 3671-3674 Published: DEC 1 2000 |
| Times Cited: 247 References: 22 |
| Abstract: Standardized criteria for assessing response are essential to ensure comparability among clinical trials for patients with myelodysplastic syndromes (MDS). An international working group of experienced clinicians involved in the management of patients with MDS reviewed currently used response definitions and developed a uniform set of guidelines for future clinical trials in MDS. The MDS differ from many other hematologic malignancies in their chronicity and the morbidity and mortality caused by chronic cytopenias, often without disease progression to acute myeloid leukemia. Whereas response rates may be an important endpoint for phase 2 studies of new agents and may assist regulatory agencies in their evaluation and approval processes, an important goal of clinical trials in MDS should be to prolong patient survival. Therefore, these response criteria reflected 2 sets of goals in MDS: altering the natural history of the disease and alleviating disease-related complications with improved quality of life. It is anticipated that the recommendations presented will require modification as more is learned about the molecular biology and genetics of these disorders. Until then, it is hoped these guidelines will serve to improve communication among investigators and to ensure comparability among clinical trials. (C) 2000 by The American Society of Hematology. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Cheson, BD (reprint author), NCI, Execut Plaza N,Room 741, Bethesda, MD 20892 USA |
Addresses:
1. NCI, Bethesda, MD 20892 USA
2. Univ Rochester, Ctr Canc, Rochester, NY 14627 USA
3. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
4. Ctr Riferimento Oncol, I-33081 Aviano, Italy
5. Wayne State Univ, Karmanos Canc Ctr, Detroit, MI USA
6. Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
7. Univ Rotterdam Hosp, Rotterdam, Netherlands
8. Univ Nijmegen Hosp, Rijmegen, Netherlands
9. Dana Farber Canc Inst, Boston, MA 02115 USA
10. Hasharon Hosp, Rabin Med Ctr, IL-49372 Petah Tiqwa, Israel
11. Tel Aviv Univ, IL-69978 Tel Aviv, Israel
12. Univ Valencia, Hosp La Fe, Valencia, Spain
13. Ziekenhuis The Hague, The Hague, Netherlands
14. Johns Hopkins Oncol Ctr, Baltimore, MD USA
15. Stanford Univ, Med Ctr, Palo Alto, CA 94304 USA
16. Vet Adm Hosp, Palo Alto, CA USA |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 377LA |
| ISSN: 0006-4971 |
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