| | |  | | | | Record from Web of Science® | | | | | | |
| From marrow to brain: Expression of neuronal phenotypes in adult mice |
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| Author(s): Brazelton TR, Rossi FMV, Keshet GI, Blau HM |
| Source: SCIENCE Volume: 290 Issue: 5497 Pages: 1775-1779 Published: DEC 1 2000 |
| Times Cited: 944 References: 28 |
| Abstract: After intravascular delivery of genetically marked adult mouse bone marrow into Lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III beta -tubulin) and were able to activate the transcription factor CAMP response element-binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications. |
| Document Type: Article |
| Language: English |
| Reprint Address: Blau, HM (reprint author), Stanford Univ, Dept Mol Pharmacol, CCSR 4215,269 Campus Dr, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 379FY |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |