| | |  | | | | Record from Web of Science® | | | | | | |
| Role of Src expression and activation in human cancer |
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| Author(s): Irby RB, Yeatman TJ |
| Source: ONCOGENE Volume: 19 Issue: 49 Pages: 5636-5642 Published: NOV 20 2000 |
| Times Cited: 241 References: 77 |
| Abstract: Since the original identification of a transmissible agent responsible for the development of tumors in chickens, non known to be a retrovirus encoding the v-src gene, significant progress has been made in defining the potential functions of its human homolog, SRC, The product of the human SRC gene, c-Src, is found to be over-expressed and highly activated in a wide variety of human cancers. The relationship between Src activation and cancer progression appears to be significant. Moreover, Src may have an influence on the development of the metastatic phenotype, This review discusses the data supporting a role for c-Src as a critical component of the signal transduction pathways that control cancer cell development and growth, and provides the rationale for targeting Src in drug discovery efforts. |
| Document Type: Review |
| Language: English |
| Reprint Address: Yeatman, TJ (reprint author), Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, 12902 Magnolia Dr, Tampa, FL 33612 USA |
Addresses:
1. Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA |
| Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: 379TV |
| ISSN: 0950-9232 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |