| | |  | | | | Record from Web of Science® | | | | | | |
| Engineering aspects of enzymatic signal transduction: Photoreceptors in the retina |
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| Author(s): Detwiler PB, Ramanathan S, Sengupta A, Shraiman BI |
| Source: BIOPHYSICAL JOURNAL Volume: 79 Issue: 6 Pages: 2801-2817 Published: DEC 2000 |
| Times Cited: 51 References: 49 |
| Abstract: Identifying the basic module of enzymatic amplification as an irreversible cycle of messenger activation/deactivation by a "push-pull" pair of opposing enzymes, we analyze it in terms of gain, bandwidth, noise, and power consumption. The enzymatic signal transduction cascade is viewed as an information channel, the design of which is governed by the statistical properties of the input and the noise and dynamic range constraints of the output. With the example of vertebrate phototransduction cascade we demonstrate that all of the relevant engineering parameters are controlled by enzyme concentrations and, from functional considerations, derive bounds on the required protein numbers. Conversely, the ability of enzymatic networks to change their response characteristics by varying only the abundance of different enzymes illustrates how functional diversity may be built from nearly conserved molecular components. |
| Document Type: Article |
| Language: English |
| Reprint Address: Shraiman, BI (reprint author), Bell Labs, Lucent Technol, Room 1D-236,700 Mt Ave, Murray Hill, NJ 07974 USA |
Addresses:
1. Bell Labs, Lucent Technol, Murray Hill, NJ 07974 USA
2. Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA |
| Publisher: BIOPHYSICAL SOCIETY, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA |
| Subject Category: Biophysics |
| IDS Number: 381EH |
| ISSN: 0006-3495 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |