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| Analysis of the genome sequence of the flowering plant Arabidopsis thaliana |
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| Author(s): Kaul S, Koo HL, Jenkins J, Rizzo M, Rooney T, Tallon LJ, Feldblyum T, Nierman W, Benito MI, Lin XY, Town CD, Venter JC, Fraser CM, Tabata S, Nakamura Y, Kaneko T, Sato S, Asamizu E, Kato T, Kotani H, Sasamoto S, Ecker JR, Theologis A, Federspiel NA, Palm CJ, Osborne BI, Shinn P, Conway AB, Vysotskaia VS, Dewar K, Conn L, Lenz CA, Kim CJ, Hansen NF, Liu SX, Buehler E, Altafi H, Sakano H, Dunn P, Lam B, Pham PK, Chao Q, Nguyen M, Yu GX, Chen HM, Southwick A, Lee JM, Miranda M, Toriumi MJ, Davis RW, Wambutt R, Murphy G, Dusterhoft A, Stiekema W, Pohl T, Entian KD, Terryn N, Volckaert G, Salanoubat M, Choisne N, Rieger M, Ansorge W, Unseld M, Fartmann B, Valle G, Artiguenave F, Weissenbach J, Quetier F, Wilson RK, de la Bastide M, Sekhon M, Huang E, Spiegel L, Gnoj L, Pepin K, Murray J, Johnson D, Habermann K, Dedhia N, Parnell L, Preston R, Hillier L, Chen E, Marra M, Martienssen R, McCombie WR, Mayer K, White O, Bevan M, Lemcke K, Creasy TH, Bielke C, Haas B, Haase D, Maiti R, Rudd S, Peterson J, Schoof H, Frishman D, Morgenstern B, Zaccaria P, Ermolaeva M, Pertea M, Quackenbush J, Volfovsky N, Wu DY, Lowe TM, Salzberg SL, Mewes HW, Rounsley S, Bush D, Subramaniam S, Levin I, Norris S, Schmidt R, Acarkan A, Bancroft I, Quetier F, Brennicke A, Eisen JA, Bureau T, Legault BA, Le QH, Agrawal N, Yu Z, Martienssen R, Copenhaver GP, Luo S, Pikaard CS, Preuss D, Paulsen IT, Sussman M, Britt AB, Selinger DA, Pandey R, Mount DW, Chandler VL, Jorgensen RA, Pikaard C, Juergens G, Meyerowitz EM, Theologis A, Dangl J, Jones JDG, Chen M, Chory J, Somerville MC |
| Source: NATURE Volume: 408 Issue: 6814 Pages: 796-815 Published: DEC 14 2000 |
| Times Cited: 3,171 References: 122 |
| Abstract: The flowering plant Arabidopsis thaliana is an important model system for identifying genes and determining their functions. Here we report the analysis of the genomic sequence of Arabidopsis. The sequenced regions cover 115.4 megabases of the 125-megabase genome and extend into centromeric regions. The evolution of Arabidopsis involved a whole-genome duplication, followed by subsequent gene loss and extensive local gene duplications, giving rise to a dynamic genome enriched by lateral gene transfer from a cyanobacterial-like ancestor of the plastid. The genome contains 25,498 genes encoding proteins from 11,000 families, similar to the functional diversity of Drosophila and Caenorhabditis elegans - the other sequenced multicellular eukaryotes. Arabidopsis has many families of new proteins but also lacks several common protein families, indicating that the sets of common proteins have undergone differential expansion and contraction in the three multicellular eukaryotes. This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement. |
| Document Type: Review |
| Language: English |
Addresses:
1. Inst Genom Res, Rockville, MD 20850 USA
2. Kazusa DNA Res Inst, Kisarazu, Chiba 292 Japan
3. Univ Penn, Dept Biol, Inst Plant Sci, Philadelphia, PA 19104 USA
4. Univ Calif Berkeley, USDA, Ctr Plant Gene Express, Albany, CA 94710 USA
5. Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA
6. Salk Inst Biol Studies, La Jolla, CA 92037 USA
7. Exelixis Inc, San Francisco, CA 94083 USA
8. AGOWA Gmbh, D-12489 Berlin, Germany
9. John Innes Ctr, Norwich NR4 7UH, Norfolk England
10. QIAGEN Gmbh, D-40724 Hilden, Germany
11. Plant Res Int, Greenomics, NL-6700 AA Wageningen, Netherlands
12. GATC Gmbh, D-78467 Constance, Germany
13. SRD Gmbh, D-61440 Oberursel, Germany
14. Univ Ghent, VIB, Dept Plant Genet, B-9000 Ghent, Belgium
15. Katholieke Univ Leuven, Lab Gene Technol, B-3001 Leuven, Belgium
16. Genoscope & CNRS FRE2231, F-91057 Evry, France
17. Genotype Gmbh, D-69259 Wilhemlsfeld, Germany
18. European Mol Biol Lab, Biochem Instrumentat Program, D-69117 Heidelberg, Germany
19. LION Biosci AG, D-69120 Heidelberg, Germany
20. MWG Biotech AG, D-69117 Ebersberg, Germany
21. Univ Padua, CRIBI, I-35131 Padua, Italy
22. Washington Univ, St Louis Sch Med, Washington Univ Genome Sequencing Ctr, St Louis, MO 63108 USA
23. Cold Spring Harbor Lab, Lita Annenberg Hazen Genome Ctr, Cold Spring Harbor, NY 11724 USA
24. Celera Genomics, Foster City, CA 94494 USA
25. Cold Spring Harbor Lab, Plant Biol Grp, Cold Spring Harbor, NY 11724 USA
26. Max Planck Inst Biochem, GSF Forschungszentrum Umwelt & Gesundheit, Munich Informat Ctr Protein Sequences, D-82152 Munich, Germany
27. Inst Genomic Res, Rockville, MD 20850 USA
28. John Innes Ctr, Molec Genet Dept, Norwich NR4 7UH, Norfolk England
29. Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
30. Cereon Genomics LLC, Cambridge, MA 02139 USA
31. Max Planck Gesell, Max Delbruck Lab, D-50829 Cologne, Germany
32. John Innes Ctr, Brassicas & Oilseeds Res Dept, Norwich NR4 7UJ, England
33. Ctr Natl Sequencage, Genoscope, F-91057 Evry, France
34. Univ Ulm, Molek Bot, D-89069 Ulm, Germany
35. McGill Univ, Dept Biol, Montreal, PQ H3A 1B1 Canada
36. Univ Chicago, Howard Hughes Med Inst, Chicago, IL USA
37. Washington Univ, Biol Dept, St Louis, MO 63130 USA
38. Univ Wisconsin, Biotechnol Ctr, Madison, WI 53706 USA
39. Univ Calif Davis, Sect Plant Biol, Davis, CA 95616 USA
40. Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA
41. Univ Arizona, Dept Molec & Cell Biol, Tucson, AZ 85721 USA
42. ZMBP, Ctr Plant Molec Biol, Entwicklungsgenet, D-72076 Tubingen, Germany
43. Calif Inst Biol, Div Biol, Pasadena, CA 91125 USA
44. Univ N Carolina, Dept Biol, Coker Hall, Chapel Hill, NC 27599 USA
45. John Innes Ctr, Sainsbury Lab, Norwich NR4 7UI, Norfolk England
46. Salk Inst Biol Studies, Howard Hughes Med Inst, Plant Biol Lab, La Jolla, CA 92037 USA
47. Carnegie Inst, Stanford, CA 94305 USA |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 382PK |
| ISSN: 0028-0836 |
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