| | |  | | | | Record from Web of Science® | | | | | | |
| Orchestrated transcription of key pathways in Arabidopsis by the circadian clock |
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| Author(s): Harmer SL, Hogenesch LB, Straume M, Chang HS, Han B, Zhu T, Wang X, Kreps JA, Kay SA |
| Source: SCIENCE Volume: 290 Issue: 5499 Pages: 2110-2113 Published: DEC 15 2000 |
| Times Cited: 547 References: 34 |
| Abstract: Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than 8000 genes on the array exhibited circadian changes in steady-state messenger RNA Levers. Clusters of circadian-regulated genes were found in pathways involved in plant responses to Light and other key metabolic pathways. Computational analysis of cycling genes allowed the identification of a highly conserved promoter motif that we found to be required for circadian control of gene expression. Our study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kay, SA (reprint author), Scripps Res Inst, Res Inst, Dept Cell Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA |
Addresses:
1. Scripps Res Inst, Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
2. Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
3. Univ Virginia, Dept Internal Med, Div Endocrinol & Metab, NSF Ctr Biol Timing,Ctr Biomath Technol, Charlottesville, VA 22904 USA
4. Novartis Agr Discovery Inst, San Diego, CA 92121 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 383ER |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |