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| Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies |
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| Author(s): Artlett CM, Ramos R, Jiminez SA, Patterson K, Miller FW, Rider LG |
| Source: LANCET Volume: 356 Issue: 9248 Pages: 2155-2156 Published: DEC 23 2000 |
| Times Cited: 78 References: 5 |
| Abstract: We identified maternal microchimerism by fluorescence in-situ hybridisation in magnetically-separated CD4 or CD8 peripheral blood cells of eight of nine male patients with juvenile idiopathic inflammatory myopathy, compared with two of nine healthy male controls. We also found maternal microchimerism in inflammatory lesions (one skin sample and nine muscle biopsy samples) of all ten patients examined, compared with two of ten biopsy samples from patients with other muscle disorders. These results suggest that maternal cells may be involved in the pathogenesis of juvenile idiopathic inflammatory myopathy. |
| Document Type: Article |
| Language: English |
| Reprint Address: Artlett, CM (reprint author), Thomas Jefferson Univ, Div Rheumatol, Philadelphia, PA 19107 USA |
Addresses:
1. Thomas Jefferson Univ, Div Rheumatol, Philadelphia, PA 19107 USA
2. Childrens Hosp & Reg Med Ctr, Dept Pathol, Seattle, WA USA
3. Univ Washington, Seattle, WA 98195 USA
4. US FDA, Ctr Biol Evaluat & Res, Div Monoclonal Antibodies, Bethesda, MD USA
5. NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA |
| Publisher: LANCET LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Medicine, General & Internal |
| IDS Number: 385HD |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |