| | |  | | | | Record from Web of Science® | | | | | | |
| Cajal bodies: The first 100 years |
|
|
| Author(s): Gall JG |
| Source: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY Volume: 16 Pages: 273-+ Published: 2000 |
| Times Cited: 256 References: 135 |
| Abstract: Cajal bodies are small nuclear organelles first described nearly 100 years ago by Ramon y Cajal in vertebrate neural tissues. They have since been found in a variety of animal and plant nuclei, suggesting that they are involved in basic cellular processes. Cajal bodies contain a marker protein of unknown function, p80-coilin, and many components involved in transcription and processing of nuclear RNAs. Among these are the three eukaryotic RNA polymerases and factors required for transcribing and processing their respective nuclear transcripts: mRNA, rRNA, and pol III transcripts. A model is discussed in which Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. A parallel is drawn to the nucleolus and the preassembly of ribosomes, which are unitary particles involved in translation of proteins. |
| Document Type: Review |
| Language: English |
| Reprint Address: Gall, JG (reprint author), Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USA |
Addresses:
1. Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 385NH |
| ISSN: 1081-0706 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |