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| Short-range and long-range guidance by slit and its Robo receptors: A combinatorial code of Robo receptors controls lateral position |
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| Author(s): Simpson JH, Bland KS, Fetter RD, Goodman CS |
| Source: CELL Volume: 103 Issue: 7 Pages: 1019-1032 Published: DEC 22 2000 |
| Times Cited: 140 References: 45 |
| Abstract: Slit is secreted by midline glia in Drosophila and functions as a short-range repellent to control midline crossing. Although most Slit stays near the midline, some diffuses laterally, functioning as a long-range chemorepellent. Here we show that a combinatorial code of Robe receptors controls lateral position in the CNS by responding to this presumptive Slit gradient. Medial axons express only Robe, intermediate axons express Robo3 and Robe, while lateral axons express Robo2, Robo3, and Robe. Removal of robo2 or robo3 causes lateral axons to extend medially; ectopic expression of Robo2 or Robo3 on medial axons drives them laterally. Precise topography of longitudinal pathways appears to be controlled by a combination of long-range guidance (the Robe code determining region) and short-range guidance (discrete local cues determining specific location within a region). |
| Document Type: Article |
| Language: English |
| Reprint Address: Goodman, CS (reprint author), Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, 519 LSA, Berkeley, CA 94720 USA |
Addresses:
1. Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 386BQ |
| ISSN: 0092-8674 |
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