| | |  | | | | Record from Web of Science® | | | | | | |
| Chromosomal effects of rapid gene evolution in Drosophila melanogaster |
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| Author(s): Nurminsky D, De Aguiar D, Bustamante CD, Hartl DL |
| Source: SCIENCE Volume: 291 Issue: 5501 Pages: 128-130 Published: JAN 5 2001 |
| Times Cited: 24 References: 15 |
| Abstract: Rapid adaptive fixation of a new favorable mutation is expected to affect neighboring genes along the chromosome. Evolutionary theory predicts that the chromosomal region would show a reduced level of genetic variation and an excess of rare alleles, We have confirmed these predictions in a region of the X chromosome of Drosophila melanogaster that contains a newly evolved gene far a component of the sperm axoneme. In D, simulans, where the novel gene does not exist, the pattern of genetic variation is consistent with selection against recurrent deleterious mutations. These findings imply that the pattern of genetic variation along a chromosome may be useful for inferring its evolutionary history and for revealing regions in which recent adaptive fixations have taken place. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hartl, DL (reprint author), Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02137 USA |
Addresses:
1. Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02137 USA
2. ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32604 USA
3. Tufts Univ, Sch Med, Dept Anat & Cell Biol, Boston, MA 02111 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 389VJ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |