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| 17q21-qter trisomy is an indicator of poor prognosis in acute myelogenous leukemia |
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| Author(s): Morerio C, Russo I, Rosanda C, Rapella A, Leszl A, Basso G, Maserati E, Pasquali F, Panarello C |
| Source: CANCER GENETICS AND CYTOGENETICS Volume: 124 Issue: 1 Pages: 12-15 Published: JAN 1 2001 |
| Times Cited: 3 References: 24 |
| Abstract: A reciprocal translocation (9;11) is often found in acute myeloid leukemia (AML), mostly of the M5a type. We report a case of a child with ARAL, in whom r(9;11) was observed at diagnosis as the sole structural abnormality, together vith trisomies 19 and 21. The diagnosis was AML evolving from a myelodysplastic syndrome (MDS), and the blast morphology was undifferentiated. Chemotherapy failed to induce morphological remission and the patient's condition soon worsened. A subclone appeared and expanded during the course of the disease, with an additional unbalanced translocation (1;17) leading to trisomy of the long arm of chromosome 17 (17q). The data available from the literature on acquired anomalies involving 17q and our observation led us to postulate a specific link; between the gain of 17q and complete chemoresistance. (C) 2001 Elsevier Science Inc. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Panarello, C (reprint author), Ist Giannina Gaslini, Div Ematol & Oncol Pediat, Lgo G Gaslini 5, I-16147 Genoa, Italy |
Addresses:
1. Ist Giannina Gaslini, Div Ematol & Oncol Pediat, I-16147 Genoa, Italy
2. Univ Padua, Dipartimento Pediat Clin Pediat, Padua, Italy
3. Univ Turin, Dipartimento Pediat, I-10124 Turin, Italy
4. Univ Pavia, I-27100 Pavia, Italy |
| Publisher: ELSEVIER SCIENCE INC, 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA |
| Subject Category: Oncology; Genetics & Heredity |
| IDS Number: 395BP |
| ISSN: 0165-4608 |
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