| | |  | | | | Record from Web of Science® | | | | | | |
| A genomic view of immunology |
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| Author(s): Fahrer AM, Bazan JF, Papathanasiou P, Nelms KA, Goodnow CC |
| Source: NATURE Volume: 409 Issue: 6822 Pages: 836-838 Published: FEB 15 2001 |
| Times Cited: 30 References: 16 |
| Abstract: The outstanding problems facing immunology are whole system issues: curing allergic and autoimmune disease and developing vaccines to stimulate stronger immune responses against pathogenic organisms and cancer. We hope that the human genome sequence will reveal the molecular checks and balances that ensure both an effective immunogenic response against pathogenic microorganisms and a suitably tolerogenic response to self antigens and innocuous environmental antigens. Three synergistic approaches-sequence homology searches, messenger RNA expression profiling on microarrays, and mutagenesis in mice-provide the best opportunities to reveal, in the genome sequence, key proteins and pathways for targeting by new immunomodulatory treatments. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fahrer, AM (reprint author), Australian Natl Univ, John Curtin Sch Med Res, ACRF Genet Lab, Canberra, ACT 2601 Australia |
Addresses:
1. Australian Natl Univ, John Curtin Sch Med Res, ACRF Genet Lab, Canberra, ACT 2601 Australia
2. Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, ACT 2601 Australia
3. DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Palo Alto, CA 94304 USA |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 401QC |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |